When I start oral isotretinoin, will my acne get worse before it gets better?

In some cases, there can be a flare of the acne in the first month after starting oral isotretinoin (sold under the trade name of Accutane, and its generics is known as Sotret or Amnesty). However, to avoid this from happening, we may start a short course of prednisone (i.e. a corticosteroid commonly used to treat inflammation) to minimize the inflammation and to avoid the flare that would accompany it.

In most cases, we should start at a lower dose and incrementally increase the dose over the first one to two months for us to get used to the drug.